Pharmacy to Dose: The Critical Care Podcast

Jolie Gallagher, Recurring Guest and March Madness Bracketologist, returns to highlight corticosteroid treatment in acute exacerbations of COPD in this October Trial of the Week, the Reduction in the Use of Corticosteroids in Exacerbated COPD, aka REDUCE trial.

We first set the scene, discussing the historical use and evidence for systemic corticosteroids in AECOPD and discuss the variation in dosing as well as duration.

Then we dive into the REDUCE trial itself, discussing whether a short 5-day course was non-inferior to the standard 14-day course of systemic glucocorticoids. How critically ill were these patients? Is this the best primary outcome? Where did the duration of 5 days come from?

Before the episode closes with Where Are We Now: Have our outcomes in COPD exacerbations improved? Can we use an alternate corticosteroid? What is our guideline-recommended regimen? Biggest unanswered questions and so much more!

Related Podcast Episodes Include: COPD