Pharmacy to Dose: The Critical Care Podcast

Recurring guest Leslie Hamilton returns to highlight thrombolytic time windows in this October Trial of the Week, featuring the European Cooperative Acute Stroke Study 3 aka ECASS III.

We first set the scene, discussing the origins of thrombolytic time windows, which windows have been studied, and how was the ECASS III time chosen?

Then we dive into the ECASS III study itself, discussing the results from extended-window thrombolysis. How did this compare to the NINDS study? How did the ICH rates compare? How was stroke care different in 2008 vs 2024?

Before the episode closes with Where Are We Now? How did the ECASS III findings change guideline recommendations? What are some of the most important studies since this Trial of the Week researching extended-window thrombolysis? Do the risks outweigh the benefits? & so much more!

Related podcast episodes:
TNK in AIS
BP Control in Neurologic Emergencies Part I & Part II