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Play-In Game/First Four Matchup
#16 ALIVE “Amiodarine as compared with lidocaine for shock-resistant ventricular fibrillation”
Pubmed Link
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#16 TROICA “Thrombolysis during resuscitation for out-of-hospital cardiac arrest”
Pubmed Link


First Round Matchups
#1 Rivers EGDT “Early goal-directed therapy in the treatment of severe sepsis and septic shock”
Pubmed Link
v.
#16 Play-In Winner (ALIVE v TROICA)

#8 “Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock”
Pubmed Link
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#9 CORTICUS “Hydrocortisone therapy for patients with septic shock”
Pubmed Link


#5 VASST “Vasopressin versus norepinephrine infusion in patients with septic shock”
Pubmed Link
v.
#12 “Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial”
Pubmed Link


#4 SAFE “A comparison of albumin and saline for fluid resuscitation in the intensive care unit”
Pubmed Link
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#13 SEDCOM “Dexmedetomidine vs midazolam for sedation of critically ill patients”
Pubmed Link


#6 NICE-SUGAR “Intensive versus conventional glucose control in critically ill patients”
Pubmed Link
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#11 ECASS III “Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke”
Pubmed Link


#3 Awakening and Breathing Controlled trial “Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing controlled trial): a randomised controlled trial”
Pubmed Link
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#14 MENDS “Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial”
Pubmed Link


#7 FACTT “Comparison of two fluid-management strategies in acute lung injury”
Pubmed Link
v.
#10 LaSRS “Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome”
Pubmed Link


#2 “Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome”
Pubmed Link
v.
#15 HACA “Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest”
Pubmed Link


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