Pharmacy to Dose: The Critical Care Podcast

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First Four/Play-In Game Matchup

#12 PRODEX/MIDEX “Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials” Pubmed Link
v.
#12 ARISE “Goal-directed resuscitation for patients with early septic shock”
PROCESS “A randomized trial of protocol-based care for early septic shock”
PROMISE “Trial of early, goal-directed resuscitation for septic shock”

#1 SOAP II “Comparison of dopamine and norepinephrine in the treatment of shock”
Pubmed Link
v.
#16 ACURASYS “Neuromuscular blockers in early acute respiratory distress syndrome”
Pubmed Link

#8 BICAR-ICU “Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial”
Pubmed Link
v.
#9 SMART “Balanced crystalloids versus saline in critically ill adults”
Pubmed Link

#5 ROSE “Early neuromuscular blockade in the acute respiratory distress syndrome”
Pubmed Link
v.
#12 Play-in Winner (PRO-/MIDEX v. ARISE/PROCESS/PROMISE)

#4 PROSEVA “Prone positioning in severe acute respiratory distress syndrome”
Pubmed Link
v.
#13 ALPS “Amiodarone, lidocaine, or placebo in out-of-hospital cardiac arrest”
Pubmed Link

#6 DOSE “Diuretic strategies in patients with acute decompensated heart failure”
Pubmed Link
v.
#11 REDUCE “Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial”
Pubmed Link

#3 CRASH-2 “Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.”
Pubmed Link
v.
#14 ADRENAL “Adjunctive glucocorticoid therapy in patients with septic shock”
Pubmed Link

#7 ATACH-2 “Intensive blood-pressure lowering in patients with acute cerebral hemorrhage”
Pubmed Link
v.
#10 ATHOS-3 “Angiotensin II for the treatment of vasodilatory shock”
Pubmed Link

#2 ESETT “Randomized trial of three anticonvulsant medications for status epilepticus”
Pubmed Link
v.
#15 PROWESS-SHOCK “Drotrecogin alfa (activated) in adults with septic shock
Pubmed Link