Sweet Sixteen: 2025 Eras Bracket

The Sweet Sixteen has been voted on by the Listeners, let’s discuss the second round and preview the next round.

The votes are in, and the Sweet Sixteen of the 2025 Critical Care Trials Eras Bracket have been chosen by YOU, the listener.

Remember, vote for all 8 matchups in the Sweet Sixteen.
Voting ends Friday, March 28 at 23:59.

https://forms.gle/AqVNu8zQ2hDunb7u7

1900’s Region

Second Round Analysis
–Top 4 seeds all advanced
–#1 NINDS, #2 TRICC, and #3 LMWH Trauma VTE Prophylaxis all won in a blowout fashion
–#4 ISIS-2 escaped with a single digit victory against the Play-In #12 Meduri Steroids Unresolving ARDS (this was also the closest vote in the 2nd Round)

Sweet Sixteen Preview
–#1 NINDS v. #4 ISIS-2 — “The Fibrinolytic Finale”

–#2 TRICC v. #3 LMWH Trauma VTE Prophylaxis — “The Hemostasis Horse Race”

2000’s Region

Second Round Analysis
–Similar to 1900’s Region: “All Chalk” with. no upsets
–4 of the Top 5 seeds advance (#4 SAFE upset in the 1st Round)
–#1 Rivers EGDT and #2 ARDSNet Low Tidal Volume won in blowout fashion
–#3 Awake & Breathe advanced in a last-minute victory over #6 NICE-SUGAR
–#5 VASST ended the Cinderella run for #13 SEDCOM, the lowest seed in the entire tournament to win a matchup

Sweet Sixteen Preview
–#1 Rivers EGDT v. #5 VASST –” The Sepsis Showdown, Another One (DJ Khaled voice)”

#2 ARDSNet Low Tidal Volume v. #3 Awake & Breathe — “Pulm v. PADIS Playoff”

2010’s Region

Second Round Analysis
–Not a close game in the 2010’s region second round games
–Similar to 1900’s/2000’s regions, all top 4 seeds advance
–#1 SOAP II, #2 ESETT dominated their matchups
–#3 CRASH-2 and #4 PROSEVA both pulled away in the second half and won to advance
–Cinderella run for the Play-In #12 PRODEX/MIDEX is unfortunately over

Sweet Sixteen Preview
–#1 SOAP II v. #4 PROSEVA — “Pressors v. Proning”

–#2 ESETT v. #3 CRASH-2 — “Anti-seizure v. Anti-fibrinolytic”

2020’s Region

Second Round Analysis
–The Region of Chaos officially shifted sides of the bracket
–0 upsets in the first 3 regions
–3 upsets in this region alone
–The first #1 seed goes down, #1 RECOVERY was thoroughly beaten by #8 DEXA-ARDS
–At the same time, the #5 ACT trial dominated the #4 CAPE COD
–#6 MENDS2 upset #3 BLING III
–#2 ACORN escaped again against #10 DOREMI (2nd single digit victory in the first 2 games)

Sweet Sixteen Preview
–#5 ACT v. #8 DEXA-ARDS — “Tenecteplase v. Ten Day Course of Steroids”