Vasoactives in Septic Shock References

Here’s a PDF that has all of these references in one location! https://pharmacytodose.files.wordpress.com/2019/10/vasoactives-in-septic-shock-references-1.pdf

Guidelines/General Reviews

Sepsis-3 – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968574/

2016 Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock – https://www.ncbi.nlm.nih.gov/pubmed/28101605

NEJM Review on Severe Sepsis and Septic Shock – https://www.ncbi.nlm.nih.gov/pubmed/23984731

Surviving Sepsis Campaign Bundle: 2018 Update – https://www.ncbi.nlm.nih.gov/pubmed/29767636

Vasoactive Agents for Adult Septic Shock: An Update and Review – https://www.ncbi.nlm.nih.gov/pubmed/31057085

Vasoactive Drugs in Circulatory Shock – https://www.ncbi.nlm.nih.gov/pubmed/21097695

Studies Discussed During the Episode

Pharmacokinetics of oral fludricortisone – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099539/

Annane Corticosteroid Editorial – https://www.ncbi.nlm.nih.gov/pubmed/31259754

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study – https://www.ncbi.nlm.nih.gov/pubmed/27940189

Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study – https://www.ncbi.nlm.nih.gov/pubmed/26771781

Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients with Septic Shock – https://www.ncbi.nlm.nih.gov/pubmed/30028362

Angiotensin II for the Treatment of Vasodilatory Shock – https://www.ncbi.nlm.nih.gov/pubmed/28528561

A Retrospective Review of Angiotensin II Use in Adult Patients with Refractory Distributive Shock – https://www.ncbi.nlm.nih.gov/pubmed/31480886

A Blast From the Past: Revival of Angiotensin II for Vasodilatory Shock – https://www.ncbi.nlm.nih.gov/pubmed/29582666

Methylene blue for the treatment of septic shock – https://www.ncbi.nlm.nih.gov/pubmed/20575634

Association Between US Norepinephrine Shortage and Mortality Among Patients with Septic Shock – https://www.ncbi.nlm.nih.gov/pubmed/28322415

Effects of Norepinpehrine and Vasopressin Discontinuation Order in the Recovery Phase of Septic Shock: A Systematic Review and Individual Patient Data Meta-Analysis – https://www.ncbi.nlm.nih.gov/pubmed/30893494

Trends in Use of Midodrine in the ICU: A Single-Center Retrospective Case Series – https://www.ncbi.nlm.nih.gov/pubmed/29613861

Future and In-Progress Research

CLOVERS trial – https://clinicaltrials.gov/ct2/show/NCT03434028

Research Priorities for Sepsis and Septic Shock – https://www.ncbi.nlm.nih.gov/pubmed/29957716

These references should augment the episode and help with further discussion/clarification on some of the issues we discussed.

If you’re looking for a specific reference or have ideas on others to add reach out via email: PharmacyToDose@Gmail.com or via Twitter/Instagram @PharmacyToDose

-Nick